Session Chair: Rawi Ramautar

Keynote Speaker: Oleg A. Mayboroda, Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands

Does mass spectrometry still need front-end separations?
Some researchers claim that (modern) mass spectrometry does not require front-end separations anymore. However, despite significant developments in mass spectrometry technology, front-end separations will remain essential in order to minimize matrix effects and to improve the reproducibility and sensitivity of the analyses of especially complex samples. Moreover, the selective analysis of isobaric and isomeric compounds requires an efficient front-end separation prior to mass spectrometric analysis.
Currently, miniaturization of separation techniques is a dominating trend in modern analytical chemistry, leading to exciting developments, not only in micro/nano-LC, capillary electrophoresis, capillary GC and microfluidic separations, but also in lab-on-a-chip, and sample pretreatment. The hyphenation of these miniaturized separation techniques to mass spectrometry (often) requires effective interface designs in order to preserve the high separation efficiency of the front-end separation and the high sensitivity of mass spectrometry. This session will provide an overview of the state-of-the-art in this area.