Session Chair: Andras Guttmann
Keynote Speaker: Gordon Lauc, University of Zagreb, Zagreb, Croatia
The importance of sugar analysis in the biomedical and biopharmaceutical fields
Glycans play vital roles in biological processes such as cell proliferation, cell–cell and cell–extra cellular matrix interactions, protein degradation, inflammation, and activation of the immune system. Specific glycosylation changes have been shown in cancer, cardiovascular and neurodegenerative diseases as well as in disorders of the immune system. These transformations are usually associated with changes in the cell surface and secreted carbohydrate profiles, therefore, tracking of specific structural changes in those glycans may lead to the discovery of new disease biomarkers.
On the other hand, there is a growing demand in the biopharmaceutical industry for comprehensive N-glycosylation profiling of carbohydrates associated with therapeutic antibodies and fusion proteins in all phases of biologics development. The presentations of this session will focus on the new developments in microscale bioseparations to address the needs of the biomedical and biopharmaceutical fields.